[dropcap]S[/dropcap]o, if you’re reading this, you are wondering about strokes. Either you, one of your parents or other loved one has had a stroke and you want answers. You may be a doctor and, like me you have been struck with the revelation that in the past 50 years we have made virtually no advances in either the immediate management of stroke victims or any impact on diminishing the long term deficits which so profoundly affect the lives of these patients and their families. Your questions could and, in fact, should include:

“What causes a stroke?”

“What kinds of strokes are there?”

“How can I prevent a stroke?”

“What happens in the Emergency Room when a new stroke patient is admitted?”

“What should be done in the Emergency Room when a new stroke is admitted?”

“What can be done if I or my loved one has a stroke?”

“Is the damage permanent?”

“What can stroke rehabilitation do for a stroke patient?”

And for physicians, “What is the neuropharmacology of a stroke?”

These questions will be answered in great detail in this chapter, perhaps even more detail than the layman might understand. However, in my attempt to change the current dogma and impotent management of this devastating process, I will need to delve into the current neuropharmacology research and this may be more science than the average person wishes to contemplate. As for the physician, our basic science training in medical school is a long time ago for most of us, but I feel certain that memories of these fundaments will quickly be refreshed in these doctors and they will unquestionably be able to understand the data and the merits of my protocols and the science on which it is based.

It is my sincere prayer that this will introduce a new protocol to the acute or emergent management of the stroke patient. It is also my hope that the research presented which is published in highly reputed journals and reviewed prior to its original publication by some of the world’s foremost scientists will be appreciated for its scientific merit and the layman and physician alike will see the potential for its practical application in the care of the stroke patient.

In addition, I would like to see, utilizing information and concepts presented in this book, well-designed scientific studies of biochemical, structural, and functional outcomes in stroke patients. Perhaps we can impact stroke outcomes by implementing these basic biochemical and neuropharmacologic interventions and bring about a long overdue change in the management of stroke.